However, generally speaking, you can expect very poor fuel economy from a Ford V10 F250. We're talking in the range of 8-12 MPG combined (city and highway driving). Highway driving might yield slightly better results (perhaps up to 15 MPG under ideal conditions), but city driving will significantly lower that figure. Towing will dramatically reduce fuel economy.
It's important to note that this is a broad estimate. Real-world mileage can vary considerably. Looking up fuel economy estimates for the *specific year* of the F250 you are interested in, from sources like the EPA or fueleconomy.gov (if available for that year), will provide a more accurate range.
