Here's why:
* Motor Mounts: The engine and transmission mounts from the Mustang won't work in the F-150. Custom motor mounts will need to be fabricated.
* Transmission Crossmember: The Mustang's transmission crossmember won't fit. A custom crossmember will be required.
* Driveshaft: The Mustang's driveshaft will be far too short. A custom driveshaft will need to be made, likely with a different yoke to match the F-150's rear axle.
* Wiring Harness: The Mustang's wiring harness will need to be modified extensively or completely replaced with a custom harness to interface with the F-150's systems.
* Exhaust System: The Mustang's exhaust system won't work. A custom exhaust system will need to be fabricated.
* Cooling System: You'll likely need to modify or replace the cooling system components to accommodate the engine's different requirements.
* Computer/ECU: The Mustang's computer may or may not be compatible with the F-150's sensors and systems. You might need a standalone engine management system.
* Body Clearance: The Mustang's engine might be too wide to fit without body modifications.
In short: This isn't a bolt-in swap. It requires significant mechanical skill, welding expertise, fabrication tools, and a good understanding of automotive electrical systems. It's a project best suited for experienced engine swappers. You'll likely spend a considerable amount of time and money making this swap work.