Where is the fuel filter on a 2001 Chevrolet Silverado large engine pickup truck?

The fuel filter location on a 2001 Chevrolet Silverado with a large engine (assuming you mean a V8, like a 4.8L, 5.3L, or 6.0L) is in the fuel tank. There isn't a separate, externally accessible fuel filter like some older vehicles. The filter is part of the fuel pump module assembly inside the tank. This means replacing it requires dropping the fuel tank.