* Engine bay modifications: The S-10's engine bay is simply too small for a 454 without major cutting and fabrication. You'd need to modify or replace the firewall, possibly the inner fenders, and potentially even the frame.
* Transmission and drivetrain modifications: The S-10's stock transmission and drivetrain components wouldn't be able to handle the power and torque of a 454. You'd need a heavy-duty transmission (likely a TH400 or 700R4, possibly a modified automatic or a manual), a stronger rear axle, and likely upgraded driveshafts.
* Suspension upgrades: The added weight of the 454 would significantly impact the S-10's handling and stability. Upgraded suspension components, including springs, shocks, and possibly a reinforced frame, would be necessary.
* Cooling system upgrades: A 454 generates significantly more heat than a stock S-10 engine. You'd need a larger radiator, higher-capacity cooling fans, and potentially an upgraded water pump.
* Exhaust system: A custom exhaust system would be required to fit the larger engine.
While it's *theoretically* possible to fit a 454 into an S-10, it's a tremendously involved and expensive project requiring significant fabrication skills and expertise. It's not a simple swap; it's a full-blown custom build. The cost and effort likely outweigh the benefits for most people.