* Lifter Geometry: Big-block cams have different lifter geometry (the shape and dimensions of the lifter) compared to small-block cams. They won't work correctly with the small block's lifters, leading to improper valve actuation and potentially serious damage.
* Cam Lobe Profile and Duration: Big-block cams are designed for larger displacement engines and have different lobe profiles (the shape of the cam lobe that pushes the lifter) and durations (the length of time a valve is open). Using a cam with significantly more duration in a smaller engine will likely lead to poor low-end torque, overlap issues, and potentially valve-to-piston interference.
* Timing Chain/Gear: The camshaft drive system (timing chain or gears) is usually different between big-block and small-block engines. Even if you could fit the cam, the timing components wouldn't match.
* Oil System: The oiling system of the engine might not be able to properly lubricate a camshaft designed for a higher-volume, higher-pressure system.
In short, while it might seem possible to force a big-block cam into a small-block, it's impractical and will likely cause significant engine damage. You must use a camshaft specifically designed for your small-block engine's specifications.