* Engine Mounts: The S-10 wasn't designed for a 327. You'll need custom engine mounts to properly secure the engine in the engine bay.
* Transmission: The stock S-10 transmission likely won't mate to the 327. You'll need a compatible transmission (e.g., a TH350, 700R4, or a T5 manual) and potentially an adapter plate.
* Exhaust: The existing exhaust system won't work. You'll need a custom exhaust system fabricated.
* Wiring: The electrical system will need to be adapted to accommodate the 327's needs.
* Cooling: The S-10's cooling system may not be sufficient for the 327, especially if it's a high-performance version. Upgrades may be needed.
* Steering: Depending on the size of the 327 and its accessories, you may need to modify or relocate steering components to provide sufficient clearance.
* Firewall: You might need to modify or replace parts of the firewall to accommodate the engine and its accessories.
In short, while it's *possible*, it's a significant undertaking requiring mechanical skills, fabrication expertise, and specialized parts. It's a project best suited for experienced engine swappers. Consider the cost of parts, labor, and potential unforeseen issues before starting.