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Will a Chevy 350 cam fit in an oldsmobile 403 block?

Yes, but there are some modifications needed. The Chevy 350 cam is roughly the same size as an Olds cam, the lifter bores will be too small. To correct this, you will need to drill the lifter bores to 0.842 in (21.4 mm). The Olds 403 and 455 will require a special bushing in the lifter bores in the correct size.