On average, a 100-pound increase in the mass of a car drops fuel efficiency by about 1%-2%, depending on the car and its aerodynamics. Therefore, 50 pounds would reduce gas mileage by less than 1%.
However, if you are carrying around a lot of extra weight in your car on a regular basis, it could eventually add up and reduce your fuel efficiency by a noticeable amount. For example, if you add 100 pounds to your car and drive 10,000 miles in a year, you will use about 100 more gallons of gas than you would if you didn't have the extra weight. This could cost you an extra $100 or more per year in gas money.
The weight of your car also has an impact on its performance. A car that weighs more will be slower to accelerate, slower to stop, and will have a longer stopping distance. So, if you are concerned about safety, you should avoid adding too much extra weight to your car.