While it is possible for a motor to run with a missing freeze plug, it is not recommended. A missing freeze plug can allow the engine coolant to leak, which can cause the engine to overheat. Overheating can damage the engine, resulting in costly repairs or replacements.
Additionally, a missing freeze plug can also allow dirt and debris to enter the engine, which can cause damage to the engine's internal components.
Therefore, it is important to ensure that all freeze plugs are in place and in good condition before operating an engine. If a freeze plug is missing or damaged, it should be replaced immediately.