* 5L40E: This is a five-speed automatic transmission that was also available in the 2000 S10 2WD with the 4.3L engine. It is less common than the 4L60E, but it offers better fuel economy and performance.
* NV3500: This is a five-speed manual transmission that was available in the 2000 S10 2WD with the 4.3L engine. It is the only manual transmission that was offered in this model year.