* Wiring Harness: The biggest hurdle will be the engine harness. The 1995 Vortec engine will have a different wiring harness than the 1993 S10. You'll likely need to either modify the 1995 harness to work with the 1993's system or use a harness from a 1995 S10. This is often the most complex part of the swap.
* Computer (PCM): The engine computer (Powertrain Control Module or PCM) from the 1995 Vortec will be incompatible with the 1993 system. You'll need the 1995 PCM, and potentially some other related components like sensors.
* Sensors: While many sensors might be compatible, some may have different connectors or require specific wiring changes.
* Exhaust Manifolds and Exhaust System: These may or may not be interchangeable. It's best to verify compatibility before attempting installation.
* Mounts: While the engine block is generally the same, there might be slight differences in the mounting points, requiring some modification or the use of different motor mounts.
* Transmission: Ensure your transmission is compatible with the 1995 Vortec. Automatic transmissions from the same era should usually work, but verify compatibility. Manual transmission swaps might require further investigation.
In short, while feasible, this swap requires a good understanding of automotive mechanics and wiring. You'll likely need to source various parts, adapt existing components, and potentially do some fabrication. It's not a beginner project. Consult a repair manual for both the 1993 S10 and the 1995 Vortec 4.3L to fully understand the complexities involved.