* Engine bay space: While the 460 is physically large, it might be possible with modifications to the firewall, inner fenders, and possibly the radiator support.
* Transmission: You'll need a transmission and associated drivetrain components (driveshaft, etc.) that are compatible with the 460. The stock Thunderbird transmission likely won't work.
* Exhaust system: A completely new exhaust system will be necessary.
* Wiring harness: The existing wiring harness will need modification or replacement to accommodate the 460's electrical needs.
* Cooling system: A larger radiator and potentially upgraded cooling fans will likely be needed to handle the heat generated by the larger engine.
* Mounting: New motor mounts will be required.
* Steering: Depending on the accessories and their placement, the steering might need adjustment.
In short, while it's *possible*, it's a major undertaking requiring significant mechanical skill and fabrication expertise. It's not a project for a beginner. It's far easier to swap in a smaller Ford big-block like a 429, which was offered in some Thunderbirds.