* Mounting Points: While the engine bay might seem similar, the mounting points for the 2.4L are different than the 2.2L. You'll likely need custom motor mounts.
* Transmission: The 2.2L and 2.4L Z24 used different transmissions. You'll need the transmission that came with the 2.4L Z24 and likely an adapter plate or custom work to mate it to the S10's existing transmission components.
* Wiring Harness: The electrical systems are different. You'll need to adapt the 2.4L's wiring harness to work with the S10's electrical system, or potentially swap in the entire Z24 harness.
* Exhaust: The exhaust system will need to be modified or replaced to fit the 2.4L.
* Computer/ECU: The 2.4L's engine control unit (ECU) is specific to that engine. This will need to be properly integrated or a stand-alone ECU might be necessary, adding complexity and cost.
In short, it's *possible*, but it's a major undertaking requiring significant mechanical knowledge, fabrication skills, and potentially substantial expense. It's not a simple bolt-in swap. You'd be better off finding a complete 2.4L donor vehicle (like a Z24 Cavalier or Sunbird) to make the parts sourcing easier, but even then, it's a complex project.