The most likely causes are:
* Transmission cooler failure: The cooler itself can develop a leak, either a crack or a seal failure. This is the most common cause.
* Transmission cooler line failure: The lines connecting the transmission to the cooler can rupture or develop leaks due to corrosion, age, or damage.
* Radiator failure: Less common, but a leak in the radiator itself, near the transmission cooler section, can allow the fluids to mix.
This is a serious problem requiring immediate attention. Driving with mixed transmission fluid and coolant will damage both the transmission and the engine, likely leading to costly repairs.