You'd be looking at extensive fabrication work, potentially including:
* Modifying or replacing the engine mounts: Completely different mounts would be needed.
* Modifying or replacing the firewall: The big-block's bulk might require cutting and reshaping the firewall.
* Modifying or replacing the radiator support: The engine's size and position could necessitate changes to the radiator and support structure.
* Custom exhaust system: The exhaust routing will need to be completely redone.
* Adjusting or replacing other components: Things like steering components, power steering lines, wiring harnesses, etc., might need to be modified or relocated to accommodate the larger engine.
In short, while theoretically possible with a massive amount of custom fabrication, it's not a simple swap and would likely be a very costly and time-consuming project. It's far more practical to consider a smaller-block Chevy or LS-series engine for a swap if you want to stay within the General Motors family.