* Configuration: The specific trim level, axle ratio, and tire size all impact MPG. Heavier configurations will get worse fuel economy.
* Driving style: Aggressive acceleration and heavy loads drastically reduce fuel efficiency.
* Terrain: Driving in mountainous areas or off-road will lower MPG compared to highway driving.
* Maintenance: Proper maintenance, including tire inflation and regular servicing, improves fuel economy.
Therefore, there's no single MPG figure. However, you can expect generally low MPG, typically in the range of 10-15 mpg combined (city and highway driving). Highway driving might yield slightly better results, while city driving will likely be significantly lower.
To get a more precise estimate, you should consult the EPA's fuel economy website (fueleconomy.gov) and search for the specific year and configuration of the F-350 you're interested in. Owner reviews and forums can also offer real-world fuel economy data.