* Motor Mounts: The Chevy small-block and the Oldsmobile engines have completely different motor mount locations. You'll need custom motor mounts.
* Transmission: The transmission bellhousing bolt patterns are different. You'll need a Chevy-compatible transmission and possibly an adapter plate.
* Steering: The steering linkage and possibly the steering column may interfere with the engine's placement.
* Exhaust: The exhaust manifolds or headers will need to be custom-fabricated or adapted.
* Wiring: The wiring harness will be entirely incompatible. A custom harness will be required.
* Radiator: The radiator might need to be changed or modified to fit properly.
While it's *possible* with considerable fabrication and custom parts, it's not a straightforward swap. It requires a good level of mechanical expertise and access to fabrication tools. Many professionals would consider this a fairly involved project.