* Year of the truck: Fuel economy improved slightly over the years the engine was produced.
* Transmission: Automatic or manual transmissions affect fuel economy.
* Truck configuration: A heavier-duty truck with added features will get worse fuel economy than a lighter, more basic model.
* Driving style: Aggressive driving significantly reduces fuel economy.
* Terrain and driving conditions: Towing, hauling heavy loads, and driving in mountainous areas will dramatically reduce MPG.
While you won't find a single definitive answer, you can expect to see highway MPG somewhere in the 15-20 mpg range, and significantly lower in city driving or when towing. Expect lower figures if the truck is older or poorly maintained. Real-world results may be lower than EPA estimates.
To find a more precise estimate, searching for fuel economy data specific to the *year* of your Dodge 2500 (or the year of the truck you're interested in) is recommended. You can find this information on websites specializing in vehicle specifications or online forums dedicated to Dodge trucks and the Cummins engine.