* Different Bolt Patterns: The transmission's output shaft will have a different bolt pattern to mate with the transfer case. The S10's transfer case is designed for a smaller, lighter-duty transmission. A 350, especially in a heavier vehicle, requires a much more robust transmission and transfer case setup.
* Torque Capacity: The S10's transmission simply isn't designed to handle the significantly higher torque output of a 350 V8. It would likely fail quickly under the stress.
* Gear Ratios: The gear ratios in the S10 transmission are geared for a smaller engine and likely wouldn't be suitable for a 350. You'd experience poor performance and potentially damage the transmission.
To adapt a 350 to a 4x4 setup, you'd need a transmission and transfer case specifically designed for a V8 engine of that size and power output. This would typically involve a much larger and stronger transmission, like a TH350, TH400, SM465, or a newer automatic transmission. You'd also need a transfer case designed to work with that transmission. A professional mechanic experienced in this type of conversion will be required.