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Will a 4.2 liter Ford Freestar engine work in F150?

No, a 4.2L Ford Freestar engine will not directly work in an F-150. While both are Ford vehicles, they have significantly different engine mounts, transmission compatibility, and overall chassis designs. The Freestar engine is designed for a minivan, while the F-150 is a truck requiring a much more robust and powerful engine. You'd need extensive and likely impractical modifications to even attempt it, and the result wouldn't be reliable or safe.