* Engine condition: Wear and tear on components can affect optimal timing.
* Fuel type: The type of gasoline used (leaded or unleaded) influences the ideal timing. (Remember, these engines were designed for leaded fuel.)
* Altitude: Higher altitudes require different timing settings.
* Vacuum advance: The vacuum advance mechanism on the distributor plays a significant role and its condition/operation affects the total timing.
You need to consult your owner's manual or a reputable repair manual specific to your 1974 Ford F100 300 straight-6. These manuals will provide the base timing specification (often stated as degrees BTDC - Before Top Dead Center) and instructions on how to adjust the timing using a timing light.
Without access to the correct manual, attempting to guess the timing is risky and could damage your engine. The base timing is typically around 8-10 degrees BTDC, but this is just a rough estimate, and the final setting will depend on how the vacuum advance functions. Always use the specifications provided in a trusted source.