* Driving conditions: City driving will yield significantly lower MPG than highway driving. Stop-and-go traffic drastically reduces fuel efficiency.
* Vehicle condition: A well-maintained engine and properly inflated tires will improve MPG. Issues like a faulty oxygen sensor or air filter can significantly decrease fuel economy.
* Driver habits: Aggressive driving (rapid acceleration and braking) reduces MPG.
* Payload: Carrying a heavy load will reduce MPG.
* Tire size and type: Larger or less efficient tires reduce fuel economy.
While it's impossible to give a precise number, you should expect somewhere in the range of 15-25 MPG. You're more likely to be on the lower end of that range in city driving and the higher end on the highway. Anything significantly outside of that range might suggest a problem with the vehicle that needs attention.
To get a better idea of what *your* specific truck should be getting, check the owner's manual (if you have it) for the EPA estimates. However, bear in mind those are ideal figures and real-world results often differ.