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Can you run a Nissan 280Z on only 4 cylinders?

No, you cannot reliably run a Nissan 280Z on only four cylinders. The 280Z has a six-cylinder engine. While you might be able to *force* some cylinders to not fire by disconnecting spark plugs or fuel injectors, the engine would run extremely poorly, likely overheat, and could cause significant damage. It's not designed to operate in that way.