* Engine Mounts: You'll need engine mounts specifically designed for a 350 in a Blazer. The stock mounts are for the original engine (likely a smaller V6 or a different V8).
* Transmission: The transmission must be compatible with the 350. This could involve using a different transmission entirely or adapting the existing one. The transfer case compatibility will also need to be checked.
* Exhaust System: The exhaust system will need to be fabricated or replaced to accommodate the larger engine.
* Wiring Harness: The wiring harness may need modifications to handle the 350's requirements.
* Cooling System: The cooling system might need upgrades to handle the heat generated by the larger engine. A larger radiator may be necessary.
* Steering Clearance: Depending on the accessories (alternator, power steering pump, etc.) used, clearance for the steering components may be an issue.
* Firewall Clearance: In some cases, modifications to the firewall might be needed.
In short, while it's *possible*, it's not a simple bolt-in swap. It's a significant undertaking requiring mechanical expertise, fabrication skills, and likely some custom parts. Researching specific engine mounts, transmission compatibility, and potential clearance issues is crucial before starting the project.