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Can straight 6 250 engine be mated to 350 turbohydo transmission?

No, a straight-6 250 engine cannot be directly mated to a 350 TurboHydramatic transmission without significant modification. The bolt patterns, bellhousing dimensions, and input shaft size are all different and incompatible between the two. You'd need an adapter plate (which might not even exist readily for that specific combination) and likely other modifications to the transmission or engine to make them work together. The project would be very complex and expensive.
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