* Engine size: E-250s came with a range of engine options over the years, from V6 to V8, with different displacements. Larger engines generally have lower fuel economy.
* Transmission: Automatic transmissions typically consume slightly more fuel than manual transmissions (though manuals are rare in E-250s).
* Cargo weight: The heavier the load, the lower the fuel economy.
* Driving conditions: City driving results in lower MPG than highway driving.
* Vehicle condition: Proper maintenance affects fuel efficiency.
* Year of manufacture: Fuel efficiency standards have improved over time.
Therefore, there's no single answer to how many gallons per mile a Ford E-250 uses. Instead of gallons *per mile* (which is the inverse of miles per gallon and would be a very small number), it's more helpful to look at miles per gallon (MPG). Expect figures in the range of 10-18 MPG for most E-250 models, with the lower end being more likely in city driving or with heavier loads. Older models and those with larger engines will likely be closer to the lower end of that range.
To get a more precise estimate for a *specific* E-250, you'd need to know its year, engine, and transmission, and check the EPA fuel economy estimates for that particular model year. You can find this information on the EPA's website (fueleconomy.gov) or in the owner's manual.
