* Engine Bay Space: While a Blazer has room for a V8, the 2002 Blazer likely came with a smaller V6 or V8. A 350 might require modifications to the engine bay, including potential firewall modifications, to fit properly.
* Transmission: The existing transmission is likely not compatible with a 350. You'll need a compatible transmission (likely a TH350, TH400, 700R4, or a modern equivalent) and potentially a custom driveshaft.
* Mounting: New engine mounts will be needed.
* Wiring Harness: The existing wiring harness won't be compatible. You'll need a custom harness or significant rewiring.
* Exhaust System: A new exhaust system will be necessary.
* Computer/ECU: The engine management system (computer) will need to be adapted or replaced. This is often a complex task, requiring tuning and potentially a standalone engine management system.
* Cooling System: The existing cooling system might not be sufficient for a 350 V8; upgrades may be needed.
* Brakes: The increased power of the 350 may require upgraded brakes for safety.
* Legal Considerations: In some areas, significant modifications to a vehicle may require inspection and approval before the vehicle can be legally operated on public roads.
In short, while technically feasible, it's a major project requiring mechanical expertise, welding skills, fabrication abilities, and specialized tools. It's not something a beginner mechanic should attempt. The cost will likely exceed the value of the Blazer itself unless you're doing most of the work yourself. Consider the complexity and cost carefully before undertaking such a project.