* Ignition System Problems: A faulty ignition system (distributor cap, rotor, wires, coil) can cause misfires that lead to unburnt fuel igniting in the intake manifold.
* Vacuum Leaks: Large vacuum leaks can disrupt the proper air/fuel mixture, leading to backfires.
* Fuel Delivery Problems: Issues with fuel injectors, fuel pressure regulator, or the fuel pump itself can cause a rich or lean condition, potentially resulting in a backfire.
* Intake Manifold Leaks: Cracks or leaks in the intake manifold can allow unburnt fuel to accumulate and ignite.
* Engine Timing: Incorrect engine timing can cause serious misfires and backfires.
A backfire through the throttle body can damage the throttle body itself, the intake manifold, and even the engine. It's a situation that requires immediate attention from a qualified mechanic. Don't continue driving the car until it's been diagnosed and repaired.