* Different Engine Mounts: The 350 Chevy uses different engine mounts than the Oldsmobile V8s (or V6s) that originally came in the Cutlass Supreme. You'll need custom motor mounts.
* Transmission Compatibility: You'll need to consider the transmission. The original transmission in the Cutlass might not be compatible with the 350 Chevy. You might need a different transmission (like a TH350, TH400, or a 700R4) and the associated bellhousing, driveshaft, and possibly even the rear end.
* Exhaust System: The exhaust system will need to be custom fabricated to fit the 350 Chevy's headers or exhaust manifolds.
* Wiring Harness: The wiring harness will need modification or replacement to accommodate the 350 Chevy's electrical needs.
* Cooling System: The cooling system may need modifications to handle the increased heat output of the larger engine. The radiator may need upgrading.
* Body Modifications: Depending on the size of the 350 Chevy and the accessories used (e.g., air conditioning, alternator), you may need to modify the engine bay to provide sufficient clearance.
In short, while it's *possible*, it's a significant undertaking requiring mechanical expertise, fabrication skills, and specialized tools. It's not a weekend project. You'll likely need to source custom parts and potentially consult with experienced mechanics or engine swap specialists.
