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Where is the thermostat located on a 2001 ford F150 4.6 engine?

The 2001 Ford F-150 4.6L engine's thermostat is located on the engine, at the lower intake manifold. It's not readily visible without removing some components. You'll likely need to remove parts of the upper intake plenum to access it. A repair manual specific to your year and engine is highly recommended for proper access and replacement.