* Engine bay space: While the Blazer has space for a V8, the 350 is larger and heavier than the stock engine (likely a 4.3L V6). You'll likely need to modify or replace the motor mounts, possibly even the firewall or radiator support.
* Transmission: The 350 will require a different transmission and associated components (driveshaft, transfer case, etc.). A TH350, TH400, or a more modern automatic would be common choices, but adapting them will require custom work. A manual transmission swap is also possible but even more complex.
* Exhaust system: The existing exhaust system will definitely not fit. A custom exhaust system will need to be fabricated.
* Wiring harness: You'll need a wiring harness compatible with the 350 and the chosen transmission. This often involves significant rewiring and potentially adding a stand-alone engine management system (e.g., a carburetor, or a custom-tuned EFI system).
* Cooling system: The stock cooling system might be inadequate for the larger engine. An upgraded radiator, hoses, and possibly a different fan setup will be needed.
* Fuel system: You might need to upgrade the fuel pump and lines to handle the increased fuel demand of the 350.
* Brakes: The larger and heavier engine might require an upgrade to the braking system for improved stopping power.
In short, this is not a project for a beginner. It requires significant mechanical knowledge, fabrication skills, and access to specialized tools and parts. You'll be spending a considerable amount of time and money. If you're not experienced in automotive mechanics, it's strongly recommended to seek the help of a professional mechanic experienced in engine swaps.
