* Motor Mounts: The mounting points for the 4.6L are in completely different locations. Custom motor mounts would be required.
* Transmission: The 4.6L typically uses a different transmission than the 3.8L. You'd need to swap the transmission as well, potentially necessitating modifications to the transmission tunnel.
* Wiring Harness: The wiring harnesses are entirely different. A new harness or extensive rewiring would be necessary.
* Exhaust System: The exhaust system will not fit. A new system would be required.
* Cooling System: The cooling system might need modifications or replacement to handle the larger engine.
* Other Components: Other components like the power steering system, air conditioning system, and accessories may also require modification or replacement.
In short, while it's *theoretically* possible with extensive fabrication and modification, it's a very major undertaking, far beyond a simple engine swap. It would be a very costly and time-consuming project. It's usually simpler and more cost-effective to find a Mustang that already came with the 4.6L engine.