Fuel System Issues:
* Leaks: Check all fuel lines, connections, and the fuel filter housing for leaks. Even a small leak can disrupt the prime. Look for wetness, fuel smell, or dripping.
* Loose Connections: Make sure all fuel lines are securely clamped and connected. Loose connections are a common culprit.
* Clogged Fuel Filter: A severely clogged fuel filter restricts fuel flow, making it difficult to maintain prime. Replace the filter.
* Faulty Lift Pump (if equipped): Some 7.3L Powerstrokes have a lift pump to assist in bringing fuel to the injection pump. A weak or failed lift pump prevents priming. Listen for the pump's hum; if it's weak or absent, it might be the issue. Many later 7.3Ls integrated the lift pump into the injection pump.
* Blocked Fuel Tank Vent: A blocked vent prevents air from escaping the tank as fuel is drawn out, creating a vacuum and hindering fuel flow.
* Water in the Fuel: Water in the fuel can cause issues and prevent proper priming. Drain the fuel/water separator (if fitted) and check for water in the fuel.
* Fuel Tank Problems: A problem with the fuel tank itself (e.g., a hole or blockage) can prevent fuel from reaching the lift pump.
* Restricted Fuel Lines: Kinks or blockages in the fuel lines can restrict fuel flow.
Injection Pump Issues (less likely, but possible):
* Injection Pump Leak: A leak in the injection pump itself can cause loss of prime. This is less common but needs to be considered.
Troubleshooting Steps:
1. Check the fuel filter: Replace it if it's dirty. This is the easiest and cheapest thing to try first.
2. Inspect all fuel lines and connections: Look for leaks, loose connections, or kinks. Tighten any loose connections and repair or replace any damaged lines.
3. Listen for the lift pump (if equipped): If it's weak or not running, this is a prime suspect.
4. Check the fuel tank vent: Ensure it's clear and not blocked.
5. Bleed the fuel system: Many 7.3L systems have bleed screws to allow you to manually remove air from the lines. This process varies depending on the year and model. Consult a repair manual or online resources for your specific engine.
6. Inspect the fuel tank: If other steps fail, it might be worth checking the condition of the fuel tank.
Important Note: If you're not comfortable working on your fuel system, it's best to take your vehicle to a qualified mechanic. Diesel fuel is flammable and working on the fuel system improperly can be dangerous. A repair manual specific to your vehicle's year and model will be extremely helpful.