Here are some of the problems that can occur if the timing chain is off 360 degrees:
* The engine will not start.
* The engine will run rough.
* The engine will make a knocking noise.
* The engine will stall.
* The engine will blow a head gasket.
* The piston will hit the valves, causing serious damage to the engine.
If you believe that the timing chain in your Toyota 22re engine is off, it is important to have it checked by a qualified mechanic as soon as possible.