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2001 S10 4.3 Vortec must be primed at the intake with gas to start Runs after that until you shut it off then have prime again Could fuel pressure regulator?

Fuel Pressure Regulator Issues

The fuel pressure regulator is a device that controls fuel pressure in the fuel injection system. If it is malfunctioning, it can

- Cause the engine to run rich or lean

- Cause the engine to stall or hesitate

- Cause the engine to be hard to start

Testing the fuel pressure regulator

You can test the fuel pressure regulator by:

1. Using a fuel pressure gauge to measure the fuel pressure in the line

Check Fuel Pressure Specifications

- Key On Engine Off (KOEO) fuel pressure: 57-62 psi (4.0 – 4.3 bar).

- Engine running: 55-61 psi (3.8 – 4.2 bar).

2. Pinching off the vacuum line to the regulator. Check Pressure - It Should increase about 10 psi

Conclusion

If the regulator is not working properly, you may need to replace it.