Your 2006 Honda was making noise when you can up to speed on the highway stopped and driver side rear wheel very hot let it cool started slowly with no problem What could cause?

There are a few potential causes for your 2006 Honda making a noise when you come up to speed on the highway and having a hot driver side rear wheel:

- Bad wheel bearing: A bad wheel bearing can cause the wheel to wobble and make a grinding noise. This is most likely the cause if the noise is coming from the rear of the vehicle.

- Brake problems: If the brakes are not working properly, they can cause the wheel to overheat and make a noise.

- Driveline problems: A problem with the driveshaft or differential could also cause the wheel to overheat and make a noise.

- Transmission problems: A problem with the transmission could cause the vehicle to lose power and make a noise when shifting gears.

- Loose lug nuts: If the lug nuts are not tightened properly, the wheel can come loose and make a noise.

Based on the symptoms you describe, it is most likely that the issue is a bad wheel bearing or brake problem. I recommend having your vehicle inspected by a qualified mechanic to determine the exact cause of the problem and have it repaired as soon as possible.