Number of driving hours = Distance (miles) / Average speed (miles per hour)
Number of driving hours = 1250 miles / 50 miles per hour
Number of driving hours = 25 hours
Therefore, it would take approximately 25 hours of driving to cover a distance of 1250 miles at an average speed of 50 miles per hour. Please note that this calculation does not account for factors like traffic, weather, or rest stops, which can affect the actual driving time.