Yes, there are several ways to get to Poughkeepsie via train. The most common route is to take the Metro-North Railroad Hudson Line from New York City's Grand Central Terminal. Trains run frequently throughout the day and take approximately 1 hour and 40 minutes to reach Poughkeepsie.
The other way is by taking Amtrak's Empire Service train from New York Penn Station to Poughkeepsie. This service is less frequent than the Metro-North train, but it offers more comfortable seating and amenities, and takes about 1 hour and 35 minutes.
