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Why does your 2001 Toyota Echo when you accelerate around 45 mph runs rough?

Potential Causes:

- Faulty Spark Plugs: Check the spark plugs and ensure they are in good condition, properly gapped, and not excessively worn. Replace them if necessary.

- Dirty or Clogged Fuel Injectors: Clean or replace the fuel injectors if they are dirty or clogged. This can lead to poor fuel delivery and a rough running engine.

- Faulty Ignition Coils: Check the ignition coils and make sure they are functioning properly. Replace any defective ignition coils.

- Vacuum Leak: Inspect the vacuum hoses for any leaks. A vacuum leak can cause a lean air-fuel mixture, leading to the rough running of the engine.

- Oxygen Sensor Issues: Check the oxygen sensor and ensure it is working correctly. A faulty oxygen sensor can cause the engine to run rich or lean, resulting in a rough idle.

- Fuel System Issues: Check the fuel pressure and ensure it meets the manufacturer's specifications. Replace the fuel filter if it is clogged or dirty.

- Catalytic Converter Problems: A clogged or malfunctioning catalytic converter can restrict exhaust flow and cause the engine to run roughly.

- Engine Mounts: Check the engine mounts and ensure they are in good condition. Worn or damaged engine mounts can cause the engine to vibrate excessively and run roughly.

- Transmission Problems: If the transmission is slipping, it can also cause the engine to run rough when accelerating. Check the transmission fluid level and condition, and have the transmission inspected by a qualified mechanic if there are any issues.