The V16 engine was designed by GM engineer Charles F. Kettering and his team. It was produced in two variants: a 45-degree V16 and a 90-degree V16. The 45-degree V16 had a displacement of 7.4 litres (455 cu in) and produced 185 horsepower (138 kW) at 3,200 rpm. The 90-degree V16 had a displacement of 8.5 litres (525 cu in) and produced 275 horsepower (205 kW) at 3,600 rpm.
The GM V16 was used in several luxury cars, including the Cadillac V-16, the LaSalle Series 400, and the Buick Limited Series 90. The V16 engine was also used in several racing cars, including the Duesenberg Model J and the Stutz Blackhawk.
The production of the GM V16 engine ended in 1937. It was replaced by the Cadillac V8 engine, which was more efficient and powerful.