1. Check Spark Plugs: Ensure spark plugs in cylinders 1 and 4 are in good condition, properly seated, and have the correct gap. Replace worn or damaged spark plugs.
2. Test Ignition Coils: Check the ignition coils connected to cylinders 1 and 4 for proper functioning. Replace any faulty ignition coils.
3. Inspect Fuel Injectors: Verify that the fuel injectors for cylinders 1 and 4 are working correctly. Clean or replace clogged or malfunctioning fuel injectors.
4. Examine Compression: Perform a compression test on cylinders 1 and 4 to ensure they have sufficient compression. Low compression can indicate issues with piston rings, valves, or head gasket.
5. Inspect Vacuum Leaks: Check for vacuum leaks, particularly around the intake manifold and vacuum lines, which can cause lean fuel mixture and misfires.
6. Consider Fuel Quality: Ensure you're using high-quality gasoline and avoid low-octane fuel, which may cause engine knocking and misfiring.
7. Monitor Oxygen Sensors: Check the oxygen sensors, especially upstream of the catalytic converter. Faulty oxygen sensors can disrupt air/fuel mixture and cause misfires.
8. Check Engine Wiring: Inspect the electrical wiring harness and connections related to cylinders 1 and 4. Ensure there are no loose, damaged, or corroded wires.
If you're not comfortable performing any of these checks, it's advisable to take your Toyota Sienna to a qualified mechanic for proper diagnosis and repair. They can perform detailed diagnostics using specialized equipment to pinpoint the exact cause of the misfires and provide an accurate solution.