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How much fuel or gas does a Greyhound bus use?

Greyhound buses use diesel fuel. The fuel efficiency of a Greyhound bus depends on the model and size of the bus, as well as the driving conditions. On average, a Greyhound bus gets between 4 and 6 miles per gallon. This means that a Greyhound bus traveling 500 miles will use between 83 and 125 gallons of diesel fuel.