* Towing or hauling heavy loads: Overdrive might cause the transmission to hunt for gears or overheat when towing, requiring you to disable it for better control and engine performance. Consult your owner's manual for specific towing recommendations.
* Steep inclines or mountainous terrain: Disabling overdrive can provide more engine braking and power for climbing steep hills.
* Low-speed situations requiring more engine braking: In some situations, you might want more engine braking power to help control speed on downhill stretches.
In normal everyday driving, leaving overdrive engaged is best for fuel efficiency and a smoother driving experience. Only disable it when the situations listed above apply. Your owner's manual will have the most accurate information for your specific F-150 model.