* Your mechanical experience: If you're comfortable working on cars, have used a socket set, wrench, and know how to handle grease and fluids, you might be able to tackle it. If you're a novice, it might be best to have a professional do it.
* Access: Getting to the seals requires removing components like brake drums, possibly axles, and potentially the differential cover. The ease of access varies depending on the specific configuration of your truck (wheelbase, etc).
* Tool availability: You'll need specialized tools like axle nut sockets (often large and impact-rated), a gear puller (possibly), and a seal installer. Improvising can be frustrating and potentially damage components.
* Potential complications: Seized bolts, rusted components, or damaged parts encountered during disassembly can add significantly to the difficulty.
In short: While it's not an impossible DIY project, it's a job that involves multiple steps, precise work, and the potential for things to go wrong. If you're unsure of your abilities, it's advisable to seek professional help. A mistake could lead to further damage, necessitating more extensive and expensive repairs. Consider the cost of the tools and your time compared to the cost of having a mechanic do it.