1. Make sure that the key is fully inserted into the lock cylinder. If the key is not inserted all the way, it will not be able to engage the locking mechanism.
2. Try using a different key. If you have a spare key, try using it to see if it works. If the spare key works, then the problem may be with the original key.
3. Check the door lock cylinder for damage. If the lock cylinder is damaged, it may not be able to engage the locking mechanism. Look for any signs of damage, such as cracks or breaks.
4. Check the door lock linkage. The door lock linkage is a series of rods and levers that connect the lock cylinder to the locking mechanism. If the linkage is damaged or disconnected, it may not be able to engage the locking mechanism.
5. Check the door lock actuator. The door lock actuator is a solenoid that powers the locking mechanism. If the actuator is not working, it will not be able to engage the locking mechanism.
If you are not able to identify the problem yourself, you should take your car to a qualified mechanic. They will be able to diagnose the problem and repair it.