* Lost Keys: This is the most common reason. You'll need a locksmith. They can either pick the lock, decode the lock to make a new key, or replace the lock entirely.
* Locked Keys in Ignition: If your keys are locked inside, you may need a locksmith to unlock the door or retrieve the keys. Some specialized tools can reach through the window or door jamb to unlock the door.
* Faulty Key/Lock Mechanism: The key might be worn down, or the lock mechanism itself could be jammed with dirt or debris. Try cleaning the key and the lock cylinder with compressed air and a lubricant designed for locks. If the key isn't turning smoothly, this may be the issue. If the problem persists, a locksmith or repair shop will need to investigate further.
* Electrical Issue (Power Locks): If you have power locks, check your vehicle's battery and fuses. A dead battery or blown fuse can prevent the power locks from working. Also, make sure the door lock switch is functioning correctly.
* Broken Door Handle/Latch: If the door handle is broken or the latch mechanism is malfunctioning, you'll need to replace the broken part. A mechanic or a parts store can assist with identification and replacement.
In short: For the most reliable solution, call a locksmith, especially if you've lost your keys or suspect a mechanical failure. Attempting to force the lock yourself could cause further damage.