To be certain, you should:
* Consult your owner's manual: This is the best source for the precise location.
* Use a repair manual: A Haynes or Chilton manual for your specific year, make, and model will have diagrams and instructions.
* Search online: Use a search engine with specifics like "2001 Chevy S-10 4x4 fuel filter location [engine type]", replacing "[engine type]" with your engine size (e.g., 4.3L). Look for pictures and forum posts.
Before you start looking, be aware that working with fuel systems requires caution. Always disconnect the negative battery terminal before beginning any work and take precautions to avoid sparks or open flames.