Fuel System Issues:
* Empty or Low Fuel: The most obvious, but sometimes overlooked. Check your fuel gauge.
* Fuel Pump Failure: The fuel pump might be failing to deliver fuel to the engine. This can be intermittent, explaining the sudden onset. You might hear a weak hum from the fuel pump when you turn the key (listen near the fuel tank).
* Clogged Fuel Filter: A blocked fuel filter restricts fuel flow.
* Bad Fuel Pressure Regulator: This regulates fuel pressure; a faulty one can lead to inconsistent fuel delivery.
* Fuel Injector Problems: One or more injectors might be clogged or failing to spray fuel properly.
Ignition System Issues:
* Distributor Issues (if applicable): If your S-10 has a distributor, a problem with the cap, rotor, or ignition coil could be the cause. (Less likely in a 2001, as many were transitioning to coil-on-plug systems).
* Ignition Coil(s) (Coil-on-plug systems): One or more ignition coils might be failing. This is more likely in a 2001.
* Spark Plugs & Wires: Worn, damaged, or fouled spark plugs or wires can prevent a spark.
* Crankshaft Position Sensor (CKP Sensor): This sensor tells the computer the crankshaft's position, crucial for timing the spark. A faulty CKP sensor will prevent the engine from starting, even though it cranks.
* Cam Position Sensor (CMP Sensor): Similar to the CKP, this sensor reads the camshaft's position and is critical for proper ignition timing.
Other Possibilities:
* Security System Issues: A malfunctioning anti-theft system could prevent the engine from starting.
* Battery Issues (though less likely if cranking strongly): While a weak battery might prevent starting, strong cranking suggests sufficient battery power. However, corroded terminals could still be a factor.
* Alternator Issues: While not directly preventing starting, a failing alternator could have depleted the battery over time leading to insufficient power after several attempts.
Troubleshooting Steps:
1. Check the obvious: Fuel level, battery terminals, and listen for the fuel pump hum.
2. Check for diagnostic trouble codes (DTCs): Use an OBD-II scanner to read any stored trouble codes in the engine control unit (ECU). This can significantly narrow down the problem.
3. Visual inspection: Check the spark plugs, wires, and ignition coil(s) for visible damage.
4. Test fuel pressure: If you have the tools, measuring fuel pressure will help pinpoint fuel system problems.
Recommendation:
Unless you are comfortable working on cars, taking your S-10 to a mechanic is the safest and most efficient way to diagnose and repair the problem. The information above is for educational purposes and shouldn't be taken as a definitive guide for repair. Improper repairs can lead to further damage.