You won't find one single definitive answer. However, you can expect significantly lower fuel economy than a car. Real-world MPG figures are typically in the range of 10-15 mpg combined (city and highway), and possibly slightly higher on the highway with a light load. Some owners might report slightly better or worse numbers.
To get a more precise estimate, I'd recommend checking these resources:
* The EPA's fueleconomy.gov website: Search for the specific engine size and transmission of your van. This is the best source for official estimates.
* Online car forums (like Edmunds or others): Search for owner reviews and discussions on the 2006 Chevy Express 2500. Real-world experiences can give you a better idea of what to expect.
Keep in mind that these are just estimates. Your actual mileage will vary.