The fuel filter on a 2000 Chevy S-10 is located
on the frame rail, near the fuel tank. However, the exact location can vary slightly depending on the engine and configuration of your specific truck. It's usually near the rear of the vehicle, but not directly on the tank itself.
To be certain, I strongly recommend checking your owner's manual. A diagram in the manual will show the precise location. You could also search online for a "2000 Chevy S-10 fuel filter location" image search to see pictures of where it is on similar trucks.
